International, multi-center research

Network of Neonatal Infections Supervision (neonIN)

The neonIN network is an international database developed by St. George Hospital of London that epidemiologically surveys neonatal infection, confirmed through positive cultures. This program was initiated in 2013 in two Athens pediatric hospitals, “Aghia Sophia” and “Panagiotis and Aglaia Kyriakou”, with CLEO as a partner. The findings from analyses of this network data are frequently presented at international symposia.

Vaccine Acceptance

CLEO was established in September 2013, as part of a multi-center study led by Kristen Feemster, MD, MPH, MSPHR, at the Children’s Hospital of Philadelphia (CHOP) in the United States, entitled, “Vaccine Acceptance in Three Middle Income Countries: The Impact of Attitudes towards Vaccine Safety.” This study aimed to investigate of societal attitudes toward preventative vaccination.

Data collection began in October 2013 and was completed by February 2014. Results have been submitted for publication in a scientifically prominent and internationally renowned journal. New opportunities for funding are currently being pursued to design evidence-based interventions for the dissemination of information about vaccination as a preventative measure.

Sepsis, Prevalence, Outcomes and Therapies (SPROUT)

The SPROUT global multi-center research program investigated the epidemiology, treatments and outcomes of severe sepsis and septic shock in heavily afflicted babies and children. The SPROUT study, based at CHOP, comprised 505 participating centers from across the globe. Participants from Greece included the “Aghia Sophia” and the “Panagiotis and Aglaia Kyriakou” General Hospital Units for Children’s Intensive Treatment. Results of the study have been published in international scientific journals.


CLEO was granted access to the Intercontinental Marketing Services (IMS) Health Inc. database for antibiotic prescriptions and sales. Specifically, data from 2010-2013 on antibiotic prescriptions for both children and adults in Greece were analyzed, with the objective of describing prescription patterns and estimating the annual cost of prescriptions to the insurance companies. The study results have been presented at international symposia and published in scientific journals.

ARPEC - Antibiotic Resistance and Prescribing in European Children

CLEO participated in ARPEC an EU-funded multi-center pan-European study of antibiotic prescription for hospitalized children. A total of 84 hospitals from 19 European countries participated. Results of this study have been published in scientific journals.

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CLEO was founded thanks to a grant of the “Stavros Niarchos” Foundation, which has supported its function as the main donator since 2011 and continues to do so today.