Research

International, multi-center research

Collaborative Network for European Clinical Trials for Children (c4c)

As of April 2020, CLEO participates in the Collaborative Network for European Clinical Trials for Children, conect4children (c4c) supporting the clinical monitoring across Greek sites in two studies:

  • The “TREOKAPA” study, which aims to assess the effectiveness of paracetamol in preterm babies with a patent ductus arteriosus and,
  • The “cASPerCF” study aimed at the prospective validation and clinical evaluation of a new posaconazole dosing regimen for children and adolescents with cystic fibrosis and Aspergillus infection.

Reducing Antimicrobial use and Nosocomial INfections in KIDS: A European Network (RANIN-KIDS)

RANIN-KIDS Network was founded in Athens, Greece, in March 2018, in collaboration with the European Society for Paediatric Infectious Diseases (ESPID) and ESGAP, the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Antimicrobial stewardship. The long-term goal of RANIN-KIDS is to achieve optimal clinical outcomes among pediatric patients in Europe by fighting healthcare-acquired infections (HAIs) and reducing the inappropriate use of antibiotics.

Network of Neonatal Infections Supervision (neonIN)

The neonIN network is an international database developed by St. George Hospital of London that collects epidemiological data on neonatal infections based on confirmed positive cultures. The program started off in 4 London neonatal units in 2004. With CLEO as a partner, it expanded to Greece in 2013 in two of Athens’ paediatric hospitals, “Aghia Sophia” and “Panagiotis and Aglaia Kyriakou”. 

Since then and up until December 2019, CLEO has been supporting the collection of data of 10 neonatal units out of the 18 currently participating in Greece. Findings from analyses of this network are frequently presented at international symposia. For more information click here.

Vaccine Acceptance in Botswana, the Dominican Republic, and Greece

In 2013 CLEO first took part in a multi-center study led by Kristen Feemster, MD, MPH, MSPHR, from the Children’s Hospital of Philadelphia (CHOP) in the United States, aimed at investigating societal attitudes toward preventative vaccination. Data collection span from October 2013 to February 2014. Results were published in an article entitled “The impact of access to immunization information on vaccine acceptance in three countries” 2017 in the PLoS One journal.

Sepsis, Prevalence, Outcomes and Therapies (SPROUT)

The SPROUT global multi-center research program investigated the epidemiology, treatments and outcomes of severe sepsis and septic shock in heavily afflicted babies and children. The SPROUT study, based at CHOP, comprised 505 participating centers from across the globe. Participants from Greece included the “Aghia Sophia” and the “Panagiotis and Aglaia Kyriakou” General Hospital Units for Children’s Intensive Treatment. Results of the study have been published in international scientific journals.

Antibiotic prescribing in Greece 2010-2013

CLEO was granted access to the Intercontinental Marketing Services (IMS) Health Inc. database for antibiotic prescriptions and sales. Specifically, data from 2010-2013 on antibiotic prescriptions for both children and adults in Greece were analyzed, with the objective of describing prescription patterns and estimating the annual cost of prescriptions to the insurance companies. The study results were presented at international symposia and published in scientific journals, for more information, take a look at CLEO's Publications.

Antibiotic Resistance and Prescribing in European Children (ARPEC)

CLEO participated in ARPEC an EU-funded multi-center pan-European study of antibiotic prescription for hospitalized children. A total of 84 hospitals from 19 European countries participated. Results of this study have been published in scientific journals, listed in CLEO's Publications.

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CLEO was founded thanks to a grant of the “Stavros Niarchos” Foundation, which has supported its function as the main donator since 2011 and continues to do so today.

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