Perioperative antimicrobial prophylaxis in adult patients: The first multicenter clinical practice audit with intervention in Greek surgical departments

Elisavet Chorafa, Elias Iosifidis, Sotirios Tsiodras, Athanasios Skoutelis, Eleni Kourkouni, Ioannis Kopsidas, Grammatiki-Christina Tsopela, Evangelia Chorianopoulou, Christos Triantafyllou, Georgia Kourlaba, Theoklis Zaoutis, Emmanuel Roilides, and the Preventing Hospital-Acquired Infections in Greece (PHiG) investigators

Infection Control & Hospital Epidemiology, 2020 Nov;Online. DOI:https://doi.org/10.1017/ice.2020.1276

Abstract

Objective: To audit clinical practice and implement an intervention to promote appropriate use of perioperative antimicrobial prophylaxis (PAP).

Methods: This was a prospective multicenter before-and-after study, conducted in 7 surgical departments of 3 major Greek hospitalsActive PAP surveillance in adults undergoing elective surgical procedures was performed before and after implementation of a multimodal intervention. The surveillance monitored use of appropriate antimicrobial agent according to international and local guidelines, appropriate timing and duration of PAP, overall compliance with all 3 parameters and the occurrence of surgical site infections (SSIs). The intervention included education, audit, and feedback.

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A Survey on National Pediatric Antibiotic Stewardship Programs, Networks and Guidelines in 23 European Countries

Ioannis Kopsidas, Stefania Vergnano, Nikos Spyridis, Theoklis Zaoutis, Sanjay Patel

The Pediatric Infectious Disease Journal, 2020 Jul;Online. DOI:https://doi.org/10.1097/inf.0000000000002835

Abstract

Background:Misuse, overuse of antimicrobials and increasing rates of antimicrobial resistance are well-recognized problems throughout Europe. The aim of this survey was to describe the current pediatric antibiotic stewardship (PAS) landscape across Europe and identify gaps, in terms of national programs, networks and guidelines.

Methods: A survey of 17 questions was circulated in July 2019 among 24 European pediatric infectious disease researchers and clinicians, professors and heads of department on the existence of PAS programs, national networks and meetings, established competencies, metrics and guidelines.

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Increasing healthcare workers’ uptake of seasonal influenza vaccination in a tertiary-care pediatric hospital in Greece with a low-cost, tailor-made, multifaceted strategy

Ioannis Kopsidas, Grammatiki-Christina Tsopela, Stefania Maroudi-Manta, Eleni Kourkouni, Dimitrios Charalampopoulos, Alexandra Sirogianni, Madeline E. Collins, Athanasia Lourida, Georgia Kourlaba, Theoklis E. Zaoutis, Susan E. Coffin

Vaccine, 2020 Jun;38(29):4609-4615. DOI:https://doi.org/10.1016/j.vaccine.2020.05.021

Abstract

Background: Healthcare workers’ (HCW) seasonal influenza vaccination (SIV) is critical to prevent nosocomial influenza. However, HCW vaccination rates remain unacceptably low in many European institutions. A two-year three-step initiative was implemented at a tertiary-care pediatric hospital with 750 beds in Athens, Greece with the aim of increasing SIV among HCW.

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Length of stay, cost, and mortality of healthcare-acquired bloodstream infections in children and neonates: A systematic review and meta-analysis

Sofia Karagiannidou, Christos Triantafyllou, Theoklis E. Zaoutis, Vassiliki Papaevangelou, Nikolaos Maniadakis, Georgia Kourlaba

Infection Control & Hospital Epidemiology, 2020 Mar;Online. DOI:https://doi.org/10.1017/ice.2019.353

Abstract

Objective: To estimate the attributable mortality, length of stay (LOS), and healthcare cost of pediatric and neonatal healthcare-acquired bloodstream infections (HA-BSIs).

Methods: A systematic search (January 2000–September 2018) was conducted in PubMed, Cochrane, and CINAHL databases. Reference lists of selected articles were screened to identify additional studies. Case–control or cohort studies were eligible for inclusion when full text was available in English and data for at least 1 of the following criteria were provided: attributable or excess LOS, healthcare cost, or mortality rate due to HA-BSI. Study quality was evaluated using the Critical Appraisal Skills Programme Tool (CASP). Study selection and quality assessment were conducted by 2 independent researchers, and a third researcher was consulted to resolve any disagreements. Fixed- or random-effect models, as appropriate, were used to synthesize data. Heterogeneity and publication bias were evaluated.

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The Influence of National Culture and Context on Healthcare Worker Perceptions of Infection Prevention in Greek Neonatal Intensive Care Units

Vasiliki Triantafillou, Ioannis Kopsidas, Areti Kyriakousi, Theoklis E. Zaoutis, Julia E. Szymczak

Journal of Hospital Infection, 2020 Apr;104(4):552-559. DOI:https://doi.org/10.1016/j.jhin.2019.11.020

Abstract

Background: Healthcare-associated infections (HAIs) in the neonatal intensive care unit (NICU) result in increased morbidity, mortality, and healthcare costs. Rates of HAIs in Greek NICUs are among the highest in Europe. There is a need to identify the factors that influence the transmission of HAIs and implementation of prevention interventions in this setting.

Aim:To understand healthcare workers’ perceptions about HAI prevention in Greek NICUs.

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