Length of stay, cost, and mortality of healthcare-acquired bloodstream infections in children and neonates: A systematic review and meta-analysis

Sofia Karagiannidou, Christos Triantafyllou, Theoklis E. Zaoutis, Vassiliki Papaevangelou, Nikolaos Maniadakis, Georgia Kourlaba

Infection Control & Hospital Epidemiology, 2020 Mar;Online. DOI:https://doi.org/10.1017/ice.2019.353

Abstract

Objective: To estimate the attributable mortality, length of stay (LOS), and healthcare cost of pediatric and neonatal healthcare-acquired bloodstream infections (HA-BSIs).

Methods: A systematic search (January 2000–September 2018) was conducted in PubMed, Cochrane, and CINAHL databases. Reference lists of selected articles were screened to identify additional studies. Case–control or cohort studies were eligible for inclusion when full text was available in English and data for at least 1 of the following criteria were provided: attributable or excess LOS, healthcare cost, or mortality rate due to HA-BSI. Study quality was evaluated using the Critical Appraisal Skills Programme Tool (CASP). Study selection and quality assessment were conducted by 2 independent researchers, and a third researcher was consulted to resolve any disagreements. Fixed- or random-effect models, as appropriate, were used to synthesize data. Heterogeneity and publication bias were evaluated.

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The Influence of National Culture and Context on Healthcare Worker Perceptions of Infection Prevention in Greek Neonatal Intensive Care Units

Vasiliki Triantafillou, Ioannis Kopsidas, Areti Kyriakousi, Theoklis E. Zaoutis, Julia E. Szymczak

Journal of Hospital Infection, 2020 Apr;104(4):552-559. DOI:https://doi.org/10.1016/j.jhin.2019.11.020

Abstract

Background: Healthcare-associated infections (HAIs) in the neonatal intensive care unit (NICU) result in increased morbidity, mortality, and healthcare costs. Rates of HAIs in Greek NICUs are among the highest in Europe. There is a need to identify the factors that influence the transmission of HAIs and implementation of prevention interventions in this setting.

Aim:To understand healthcare workers’ perceptions about HAI prevention in Greek NICUs.

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Attributable length of stay and cost for pediatric and neonatal centralline-associated bloodstream infections in Greece

Sofia Karagiannidou, Theoklis Zaoutis, Nikolaos Maniadakis, Vassiliki Papaevangelou, Georgia Kourlaba

Journal of Infection and Public Health, 2019 May-June;12(3):372-79. DOI: https://doi.org/10.1016/j.jiph.2018.12.004

Abstract 

Background and objective: Central line-associated bloodstream infections (CLABSIs) are the most frequent pediatric hospital-acquired infections and are associated with significant morbidity and healthcare costs. The aim of our study was to determine the attributable length of stay (LOS) and cost for CLABSIs in pediatric patients in Greece, for which there is currently a paucity of data.

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Surveillance for central-line-associated bloodstream infections: Accuracy of different sampling strategies

Kourkouni E, Kourlaba G, Chorianopoulou E, Tsopela GC, Kopsidas I, Spyridaki I, Tsiodras S, Roilides E, Coffin S, Zaoutis TE; PHIG investigators.

Infection Control Hospital Epidemiology, 2018 Oct;39(10):1210-1215. DOI:https://doi.org/10.1017/ice.2018.187

Abstract 

Background: Active daily surveillance of central-line days (CLDs) in the assessment of rates of central-line-associated bloodstream infections (CLABSIs) is time-consuming and burdensome for healthcare workers. Sampling of denominator data is a method that could reduce the time necessary to conduct active surveillance.

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Establishing Nationally Representative Central Line-Associated Bloodstream Infection (CLABSI) Surveillance Data in Paediatric Patients in Greece

Kouni S, Tsolia M, Roilides E, Dimitriou G, Tsiodras S, Skoutelis A, Kourkouni E, Gkentzi D, Iosifidis E, Spyridis N, Kopsidas I, Karakosta P, Tsopela G.C, Spyridaki I, Kourlaba G, Coffin S, Zaoutis E.T, for the PHIG Investigators

Journal of Hospital Infection, 2019 Jan;101(1):53-59. DOI: https://doi.org/10.1016/j.jhin.2018.07.032

Abstract

Background: Healthcare-associated infections (HCAIs) are associated with increased morbidity and mortality and with excess costs. Central line-associated bloodstream infections (CLABSIs) are the most common HCAIs in neonates and children.

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