Colonization of Neonates with Carbapenemase-Producing Enterobacteriaceae (CPE)

K. Mougkou, A. Michos, K. Spyridopoulou, G.L. Daikos, T. Siahanidou, N. Spyridis, J. Kapetanakis, A. Korkas, M. Anagnostakou, C. Papagaroufalis, G. Baroutis, I. Labadaridis, V. Syriopoulou, T. Zaoutis

30th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID 2012)
Thessaloniki, Greece, May 8-12, 2012

BACKGROUND: Enterobacteriaceae are among the most common human pathogens causing severe infections such as pneumonia, bacteraemia and meningitis. Escherichia coli and Klebsiella pneumoniae remain the two most frequent causes of Gram - negative blood infections with high mortality rate, especially in neonates. In the past few years, acquired carbapenemases are emerging resistance determinants in Gram - negative bacteria. Carbapenemase – Producing Enterobacteriaceae (CPE) are often resistant to all β - lactam antibiotics and frequently co - resistant to aminoglycosides, trimethoprim/sulfamethoxazole and fluoroquinolones. Carbapenemases have spread in multiple adult hospitals in Greece, where they have attained a high level of endemicity.

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