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LESSONS from COVID-19: Prevention, the key to infection control

"The coordinated actions by the Greek health authorities but also the immediate adoption of basic measures of prevention that control the transmission of the new virus by the vast majority of citizens, show that we already have suitable defense mechanisms at hand. The ultimate goal and opportunity now is for prevention practices to become permanently integrated into our daily lives, even after the COVID-19 pandemic. This way we can stop losing lives every year from the flu and other infections that can otherwise be prevented " says Dr Theoklis Zaoutis, Professor of Pediatrics and Epidemiology and Scientific Director of CLEO.

o far, COVID-19 mortality appears to be relatively low, with those who are most severely affected suffering from existing health conditions. But, while most cases of COVID-19 may be mild, the virus is more threatening – in the epidemiological sense- than would a virus which caused more severe symptoms. Those with an asymptomatic infection may not be aware of having contracted the virus, they may not take additional precautions to minimize their role in transmission, nor seek to receive adequate medical care. Unnoticed the virus may continue spreading widely, so much as to see large increases in prevalence and a domino effect not only each health system but also on the national and global economy.

One of the most important factors in limiting the spread of COVID-19 is the uptake of personal protection and prevention measures by all citizens. Another is the systematic adoption of infection control procedures by healthcare workers, who more than any other group are at greater risk of infection through the close contact with infected cases and environments. Basic precautions, such as good hand hygiene and the safe disposal of clinical waste, and transmission precautions, such as the use of isolated, clearly marked isolation areas and suitable personal protective equipment (e.g. masks, robes, goggles and gloves), are essential.
Infected patients should be moved as little as possible into and within a healthcare unit and when such movement cannot be avoided, patients should be isolated from healthcare staff and other patients through the use of dividers, curtains and appropriate air filtration systems. All healthcare professionals should be trained in infection control precautions and hospitals should be in close contact and cooperation with public health authorities in order to share up-to-date and accurate information about the spread of the virus.

The most important of these precautions – e.g. hand washing, wearing robes and gloves, and disinfecting or disposing of contaminated equipment, are quick, simple and low-cost practices that should become "second nature" not only to those who work in a healthcare environment but also to the wider public.

COVID-19 can teach us an important lesson about the urgent need for increased awareness around infection prevention as well as highlight the unique opportunity we now have to prioritize prevention for infection control in Greece and to take action on a permanent basis. The Greek government has recently taken an important step in this direction, introducing a Program for the Prevention and Control of Infections Related to Health Services and Antimicrobial Resistance, by law at the end of January 2020. The program is supported by a generous grant from the Stavros Niarchos Foundation within the framework of the "Health Initiative" program.

The importance of prevention, both for the health of citizens and for an effective health care system, is particularly evident now that the world is facing a public health emergency. Maximizing the use of standard precautions and best practices is vital to preventing and limiting both common infections and new pandemic diseases such as COVID-19.

The program is supported by a generous grant from the Stavros Niarchos Foundation within the framework of the "Health Initiative" program (https://www.snf.org/el/protoboulies/stirizontas-tin-ygeia-stin-ellada/).

The importance of prevention, both for the health of citizens and for an effective health care system, is particularly evident now that the world is facing a public health emergency. Maximizing the use of standard precautions and best practices is vital to preventing and limiting both common infections and new pandemic diseases such as COVID-19.

37th Annual Meeting of the European Society for Pediatric Infectious Diseases (ESPID)

The 37th Annual Meeting of ESPID (European Society for Pediatric Infectious Diseases) held in Ljubljana, Slovenia, on May 6-11, 2019, once again brought together the most important researchers in the field of pediatric infections, epidemiology and immunology, enabling trainees in the above fields to meet experts and colleagues from other countries and share their experiences. The ESPID’s programme was clinically oriented and promoted the best clinical practice for management of pediatric infections while it covered a wide range of educational seminars and interaction between trainees and faculty was strongly encouraged.
The CLEO team, headed by Prof. Theoklis Zaoutis, attended this year's conference and participated with the following abstracts:

1. The impact of a national electronic prescribing system on antibiotic prescribing in pediatric outpatients in Greece.

2. Impact of a care bundle on hand hygiene compliance rates in 15 neonatal intensive care units in Greece.

3. Ventilator- Associated Events in three PICUs in Greece.

4. Length of stay, cost and mortality of healthcare-acquired bloodstream infections in children and neonates A systematic review and meta-analysis.

5. Greek medical students’ perceptions, knowledge, and education about antimicrobial prescribing and resistance a cross-sectional study.

6. Central- line associated bloodstream infections in pediatric hematology units in Greece 2016- 2018. Impact of an intervention bundle.

7. Hospital- acquired infection surveillance among 11 European countries. A RANIN- KIDS survey.

The CLEO team also participated in the 11th ESPID RESEARCH MASTERCLASS (ERMC), a closed, seminar type of forum for active pediatric infectious diseases (PID) research groups in Europe. The primary aim of ERMC is to provide participants with a broad overview of the current research programs within ESPID. During Masterclass, young researchers are trained in how to present their data, ask questions or chair a session. The second objective of the seminar is to enhance the opportunities for future cooperation between ESPID members / teams.

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Collaborative Center for Clinical Epidemiology and Outcomes Research (CLEO)-Ilisia

Job Responsibilities:
As a CRA you will:

  • Prepare submission packets for hospital ethical committees (ERBs) and administrative boards, the National Ethics Committee (EED), and the National Organization for Medicines in Greece (EOF) for protocol approval
  • Be responsible for adherence to monitoring procedures in accordance with GCP and ICH, local regulations, and Standard Operating Procedures
  • Perform monitoring activities from pre-study start-up to study close-out. This may include, but is not limited to, conducting site facilities inspections, site initiation visits, on-site study specific training, ensuring completeness and quality of on-site files, electronic case report forms (eCRF) review, query generation and resolution, monitoring patient safety (adverse events, serious adverse events), addressing protocol deviations, and completing monitoring reports (as applicable)


Minimum requirements:

  • University/college degree in scientific or healthcare discipline, or comparable
  • 2+ years clinical research experience (prior pharmaceutical industry/contract research organization experience relating to clinical monitoring is a plus)
  • Fluency in written and verbal English and Greek
  • Computer literacy, including Microsoft Word, Excel, and PowerPoint
  • Prior database experience
  • Solid understanding of ICH-GCP guidelines
  • Strong communication skills and attention to detail
  • Ability to manage sites independently. Proven ability to work independently with minimal supervision
  • Ability to anticipate potential issues and take appropriate actions with or without supervision
  • Ability to travel approximately 25%-50% of the time to sites within Greece

Work location: Athens, Greece
Employment type: Full-time position
Submit your application until: 26/11/2018


Please send your CV and a cover letter at info@cleoresearch.org.

36th Annual Meeting of the European Society for Pediatric Infectious Diseases (ESPID)

The 36th Annual Meeting of ESPID (European Society for Pediatric Infectious Diseases) held in Malmö, Sweden, on May 28 - June 2, 2018, included a wide range of educational seminars and lectures on the latest developments in the field of pediatric infections, epidemiology and immunology. The conference was attended by pediatricians, infectious practitioners, microbiologists and distinguished researchers from all over the world and presented original research work on the whole range of pediatric infections.
The CLEO team, headed by Prof. Theoklis Zaoutis, attended this year's conference and participated with the following abstracts:

1. Variability of length of therapy for possible early onset sepsis (EOS) and late onset sepsis (LOS): identifying opportunities for antibiotic stewardship in the neonatal intensive care unit (NICU).
2. Variability in empiric antibacterial and antifungal use in pediatric oncology patients with febrile neutropenia.
3. Central line associated bloodstream infections in neonatal and pediatric units in greece.
4. Hand hygiene compliance rates and barriers in pediatric units in greece.
5. Surveillance for central line-associated bloodstream infections (CLABSIs): accuracy of different sampling strategies.
6. Vaccination during pregnancy: Women in Greece are unaware and express concerns for safety
7. Neonates treated for meningitis in a neonatal infection surveillance network (NEONIN)
8. Culture-proven infections in late preterm infants in a neonatal infection surveillance network (NEONIN)
9. Community onset central line associated bloodstream infections (CO-CLABSIs) in pediatric oncology patients: an underestimated problem?
10. Risk factors for community onset central line associated bloodstream infections (CO-CLABSIs) in pediatric oncology patients

The CLEO team also participated in the 10th ESPID RESEARCH MASTERCLASS (ERMC), a closed, seminar type of forum for active pediatric infectious diseases (PID) research groups in Europe. The primary aim of ERMC is to provide better opportunities for young researchers to present their studies and discuss their research with other junior colleagues as well as with European research group leaders. During the Masterclass, the junior researchers will be trained how to present their data, ask questions or chair a session. The second aim of the seminar is to provide the researchers a better view of recent PID research in Europe and also to stimulate discussions of new research collaborations among ESPID members.